Consistent model selection for estimating functional interactions among stochastic neurons with variable-length memory

TL;DR

This paper introduces a consistent model selection method for identifying functional interactions among stochastic neurons with variable-length memory, validated through simulations and real hippocampal neuron data analysis.

Contribution

It proposes a novel model selection procedure based on maximum likelihood estimation for neuronal networks with variable-length memory, ensuring consistency and practical applicability.

Findings

Validated the method with simulated data

Reconstructed spike activity in hippocampal neurons

Revealed biologically relevant interactions

Abstract

We address the problem of identifying functional interactions among stochastic neurons with variable-length memory from their spiking activity. The neuronal network is modeled by a stochastic system of interacting point processes with variable-length memory. Each chain describes the activity of a single neuron, indicating whether it spikes at a given time. One neuron's influence on another can be either excitatory or inhibitory. To identify the existence and nature of an interaction between a neuron and its postsynaptic counterpart, we propose a model selection procedure based on the observation of the spike activity of a finite set of neurons over a finite time. The proposed procedure is also based on the maximum likelihood estimator for the synaptic weight matrix of the network neuronal model. In this sense, we prove the consistency of the maximum likelihood estimator {followed} by a proof of the consistency of the neighborhood interaction estimation procedure. The effectiveness of the proposed model selection procedure is demonstrated using simulated data, which validates the underlying theory. The method is also applied to analyze spike train data recorded from hippocampal neurons in rats during a visual attention task, where a computational model reconstructs the spiking activity and the results reveal interesting and biologically relevant information.