Glucose Sensing Using Pristine and Co-doped Hematite Fiber-Optic sensors: Experimental and DFT Analysis

TL;DR

This study compares pristine and Co-doped hematite fiber-optic sensors for glucose detection, demonstrating that Co-doping enhances sensitivity and detection limits through combined experimental and DFT analysis.

Contribution

It introduces a novel Co-doped hematite fiber-optic sensor for glucose detection, combining experimental results with DFT insights to improve biosensing performance.

Findings

Co-doping reduces the limit of detection for glucose.

DFT analysis reveals enhanced charge transfer mechanisms.

Both sensors show comparable sensitivity but Co-doping improves detection limits.

Abstract

Glucose monitoring plays a critical role in managing diabetes, one of the most prevalent diseases globally. The development of fast-responsive, cost-effective, and biocompatible glucose sensors is essential for improving patient care. In this study, a comparative analysis is conducted between pristine and Co-doped hematite samples, synthesized via the hydrothermal method, to evaluate their structural, morphological, and optical properties. The glucose sensing performance of both samples is assessed using a fiber-optic evanescent wave (FOEW) setup. While the sensitivity remains comparable for both pristine and Co-doped hematite, a reduction in the Limit of Detection (LoD) is observed in the Co-doped sample, suggesting enhanced interactions with glucose molecules at the surface. To gain further insights into the glucose adsorption mechanisms, Density Functional Theory (DFT) calculations are performed, revealing key details regarding charge transfer, electronic delocalization, and glucose binding on the hematite surfaces. These findings highlight the potential of Co-doped hematite for advanced glucose sensing applications, offering a valuable synergy between experimental and theoretical approaches for further exploration in biosensing technologies.