BOston Neonatal Brain Injury Data for Hypoxic Ischemic Encephalopathy (BONBID-HIE): II. 2-year Neurocognitive Outcome and NICU Outcome

TL;DR

This paper presents the second release of BONBID-HIE, an open-source dataset with MRI and clinical data for 237 HIE patients, including NICU and 2-year neurocognitive outcomes, to aid biomarker development and prognosis.

Contribution

It introduces a comprehensive, publicly available dataset combining MRI, clinical, NICU, and neurocognitive data for HIE patients, facilitating research and biomarker discovery.

Findings

Dataset includes 237 patients with detailed MRI and clinical data.

Contains 2-year neurocognitive outcomes and NICU results.

Supports development of improved prognostic biomarkers.

Abstract

Hypoxic Ischemic Encephalopathy (HIE) affects approximately 1-5/1000 newborns globally and leads to adverse neurocognitive outcomes in 30% to 50% of cases by two years of age. Despite therapeutic advances with Therapeutic Hypothermia (TH), prognosis remains challenging, highlighting the need for improved biomarkers. This paper introduces the second release of the Boston Neonatal Brain Injury Dataset for Hypoxic-Ischemic Encephalopathy (BONBID-HIE), an open-source, comprehensive MRI and clinical dataset featuring 237 patients, including NICU outcomes and 2-year neurocognitive outcomes from Massachusetts General Hospital and Boston Children's Hospital.