Patch-Based Diffusion Models Beat Whole-Image Models for Mismatched Distribution Inverse Problems
Jason Hu, Bowen Song, Jeffrey A. Fessler, Liyue Shen

TL;DR
This paper introduces a patch-based diffusion model approach for inverse problems that outperforms whole-image models in mismatched distribution scenarios, especially with limited or single test samples, reducing artifacts and hallucinations.
Contribution
The authors propose a novel patch-based diffusion prior that learns from image patches, enabling high-quality reconstructions under distribution mismatch with minimal training data.
Findings
Patch-based models outperform whole-image models in OOD settings.
Patch approach reduces artifacts and hallucinations.
Method competes with models trained on large in-distribution datasets.
Abstract
Diffusion models have achieved excellent success in solving inverse problems due to their ability to learn strong image priors, but existing approaches require a large training dataset of images that should come from the same distribution as the test dataset. When the training and test distributions are mismatched, artifacts and hallucinations can occur in reconstructed images due to the incorrect priors. In this work, we systematically study out of distribution (OOD) problems where a known training distribution is first provided. We first study the setting where only a single measurement obtained from the unknown test distribution is available. Next we study the setting where a very small sample of data belonging to the test distribution is available, and our goal is still to reconstruct an image from a measurement that came from the test distribution. In both settings, we use a…
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Taxonomy
TopicsImage and Signal Denoising Methods · Medical Image Segmentation Techniques
MethodsDiffusion
