Order of Addition in Mixture-Amount Experiments

TL;DR

This paper develops efficient experimental designs for mixture-amount experiments considering the order of addition, using optimization algorithms to balance design efficiency and number of runs, enabling better estimation of effects.

Contribution

It introduces a method to select optimal subset designs for order-of-addition mixture experiments that maximize G-efficiency while controlling experimental runs.

Findings

Designs support estimation of mixture and order effects

Threshold Accepting algorithm effectively selects efficient designs

FDS plots visually assess design prediction capabilities

Abstract

In a mixture experiment, we study the behavior and properties of $m$ mixture components, where the primary focus is on the proportions of the components that make up the mixture rather than the total amount. Mixture-amount experiments are specialized types of mixture experiments where both the proportions of the components in the mixture and the total amount of the mixture are of interest. In this paper, we consider an Order-of-Addition (OofA) mixture-amount experiment in which the response depends on both the mixture amounts of components and their order of addition. Full mixture OofA designs are constructed to maintain orthogonality between the mixture-amount model terms and the effects of the order of addition. \answer{But the number of runs in such full OofA designs increases as $m$ increases. We employ the Threshold Accepting (TA) Algorithm to select an n-row subset from the full Order-of-Addition (OofA) mixture design that maximizes G-optimality while minimizing the number of experimental runs. Further, the G-efficiency criterion is used to assess how well the design supports the precise and unbiased estimation of the model parameters.} These designs enable the estimation of mixture-component model parameters and the order-of-addition effects. The Fraction of Design Space (FDS) plot is used to provide a visual assessment of the prediction capabilities of a design across the entire design space.