Photoacoustic tracking of photo-magnetically powered nanoparticles for cancer therapy

TL;DR

This paper presents a novel photo-magnetically powered nanoparticle that can be tracked in vivo using photoacoustic imaging, enhancing cancer therapy by improving nanoparticle distribution and retention within tumors.

Contribution

Development of a multifunctional nanoparticle with magnetic and optical properties for real-time tracking and improved delivery in cancer treatment.

Findings

PMNs produce strong photoacoustic signals in NIR window

Magnetic field enhances nanoparticle assembly and photothermal effects

Laser-magnetic coupling improves tumor retention and distribution

Abstract

The in vivo propulsion and monitoring of nanoparticles (NPs) have received tremendous achievements in the past decade. Developing functional NPs that can be efficiently manipulated inside the human body with a non-invasive tracking modality is critical to clinical translation. This study synthesized a photo-magnetically powered nanoparticle (PMN) with a Fe3O4 core and gold spiky surface. The Au-nanotips ensure PMNs have a strong light absorption in the second near-infrared (NIR) window and produce outstanding photoacoustic signals. The Bio-transmission electron microscopy and simulation results prove that the assembly of PMNs under a magnetic field further enhances the photothermal conversion in cells, contributing to the reduction of ambient viscosity. Photoacoustic imaging (PAI) realized real-time monitoring of PMN movements and revealed that laser plus magnetic coupling couldimprove intratumoral distribution and retention. The proposed methods exhibit excellent potential for the clinical research of cancer nanotherapies.