GAMMA-PD: Graph-based Analysis of Multi-Modal Motor Impairment Assessments in Parkinson's Disease

TL;DR

GAMMA-PD introduces a hypergraph-based framework that effectively integrates multi-modal data for analyzing motor impairment in Parkinson's disease, providing improved prediction and interpretability.

Contribution

It presents a novel hypergraph fusion method for multi-modal clinical data, capturing higher-order relationships and enabling interpretability in Parkinson's disease assessment.

Findings

Improved prediction of motor impairment symptoms.

Effective integration of imaging and non-imaging data.

Clinically relevant explanations for disease profiles.

Abstract

The rapid advancement of medical technology has led to an exponential increase in multi-modal medical data, including imaging, genomics, and electronic health records (EHRs). Graph neural networks (GNNs) have been widely used to represent this data due to their prominent performance in capturing pairwise relationships. However, the heterogeneity and complexity of multi-modal medical data still pose significant challenges for standard GNNs, which struggle with learning higher-order, non-pairwise relationships. This paper proposes GAMMA-PD (Graph-based Analysis of Multi-modal Motor Impairment Assessments in Parkinson's Disease), a novel heterogeneous hypergraph fusion framework for multi-modal clinical data analysis. GAMMA-PD integrates imaging and non-imaging data into a "hypernetwork" (patient population graph) by preserving higher-order information and similarity between patient profiles and symptom subtypes. We also design a feature-based attention-weighted mechanism to interpret feature-level contributions towards downstream decision tasks. We evaluate our approach with clinical data from the Parkinson's Progression Markers Initiative (PPMI) and a private dataset. We demonstrate gains in predicting motor impairment symptoms in Parkinson's disease. Our end-to-end framework also learns associations between subsets of patient characteristics to generate clinically relevant explanations for disease and symptom profiles. The source code is available at https://github.com/favour-nerrise/GAMMA-PD.