Using laser and ultrasound devices for breast cancer treatment: studying the effects of gold nanoparticles injection

TL;DR

This study explores a combined laser and ultrasound treatment for breast cancer using gold nanoparticles to enhance tissue necrosis and effectively target both superficial and deep tumor regions.

Contribution

It introduces a simulation-based approach demonstrating the effectiveness of combined laser and ultrasound therapy with gold nanoparticles for comprehensive breast cancer treatment.

Findings

Nanoparticles increased tissue necrosis volume.

Combined therapy eradicated superficial and deep tumor parts.

Simulation results support potential clinical application.

Abstract

Breast cancer is a disease in which cells in the breast grow out of control. After surgery, chemotherapy, and other invasive treatments, hyperthermia is a suitable choice with the minimal side effects. In this paper, the treatment of breast cancer using a combination of laser and ultrasound irradiation, in the presence of gold nanoparticles, is investigated. In the simulations, the breast tissue is represented as a multilayer structure and the tumor is supposed to consist two parts: a superficial section and a deeper region. In the initial stage, the superficial parts of the tumor, which also contain gold nanoparticles, are exposed to a continuous laser for 50 seconds followed by a cooling period of 20 seconds. Then, for deeper sections, ultrasound irradiation is utilized. The results indicated that the tissue necrosis volume was enhanced by the application of nanoparticles. Furthermore, it was demonstrated that the combinational application of both of laser and ultrasound irradiation could eradicate both the superficial parts of the tumor and the deep parts.