Optimizing the Induced Correlation in Omnibus Joint Graph Embeddings
Konstantinos Pantazis, Michael Trosset, William N. Frost, Carey E., Priebe, Vince Lyzinski

TL;DR
This paper introduces an automated method to optimize the correlation structure in joint graph embeddings, improving inference quality by addressing correlation issues in the Omnibus framework.
Contribution
It presents the first automated approach to construct Omnibus matrices that optimize correlation, including theoretical bounds and an algorithm called corr2Omni.
Findings
The classical Omnibus construction induces maximal flat correlation.
The corr2Omni algorithm effectively estimates optimal Omnibus weights.
Enhanced inference accuracy demonstrated in both simulated and real data.
Abstract
Theoretical and empirical evidence suggests that joint graph embedding algorithms induce correlation across the networks in the embedding space. In the Omnibus joint graph embedding framework, previous results explicitly delineated the dual effects of the algorithm-induced and model-inherent correlations on the correlation across the embedded networks. Accounting for and mitigating the algorithm-induced correlation is key to subsequent inference, as sub-optimal Omnibus matrix constructions have been demonstrated to lead to loss in inference fidelity. This work presents the first efforts to automate the Omnibus construction in order to address two key questions in this joint embedding framework: the correlation-to-OMNI problem and the flat correlation problem. In the flat correlation problem, we seek to understand the minimum algorithm-induced flat correlation (i.e., the same across all…
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Taxonomy
TopicsDNA and Biological Computing · Bioinformatics and Genomic Networks · Gene expression and cancer classification
