Effects of synapse location, delay and background stochastic activity on synchronising hippocampal CA1 neurons

TL;DR

This study investigates how synapse location, delay, and background activity influence the synchronization of hippocampal CA1 neurons using a Hodgkin-Huxley model, revealing complex dependencies on these parameters.

Contribution

It provides new insights into the effects of synapse placement and timing on neuronal synchronization in a realistic hippocampal neuron model.

Findings

Synchronization decreases with inhibition strength.

Synaptic location nonmonotonically affects activity.

Background activity's impact is independent of fluctuation intensity.

Abstract

We study the synchronisation of neurons in a realistic model under the Hodgkin-Huxley dynamics. To focus on the role of the different locations of the excitatory synapses, we use two identical neurons where the set of input signals is grouped at two different distances from the soma. The system is intended to represent a CA1 hippocampal neuron in which the synapses arriving from the CA3 neurons of the trisynaptic pathway appear to be localised in the apical dendritic region and are, in principle, either proximal or distal to the soma. Synchronisation is studied using a specifically defined spiking correlation function as a function of various parameters such as the distance from the soma of one of the synaptic groups, the inhibition weight and the associated activation delay. We found that the neurons' spiking activity depends nonmonotonically on the relative dendritic location of the synapses and their inhibitory weight, whereas the synchronisation measure always decreases with inhibition, and strongly depends on its activation time delay. The background activity on the somas results essentially independent on the fluctuation intensity and strongly support the importance of the balance between inhibition and excitation for neuronal synchronization.