Systematic comparison of Bayesian basket trial designs with unequal sample sizes and proposal of a new method based on power priors

TL;DR

This paper systematically compares Bayesian basket trial designs with unequal sample sizes and introduces a new method based on power priors that improves robustness and detection power.

Contribution

It provides a comprehensive comparison of existing Bayesian methods and proposes a new power prior approach that enhances robustness in basket trials with varying sample sizes.

Findings

Fujikawa's design is highly sensitive to sample size changes.

Limiting shared information improves robustness.

Power prior approach with limited sharing performs best.

Abstract

Basket trials examine the efficacy of an intervention in multiple patient subgroups simultaneously. The division into subgroups, called baskets, is based on matching medical characteristics, which may result in small sample sizes within baskets that are also likely to differ. Sparse data complicate statistical inference. Several Bayesian methods have been proposed in the literature that allow information sharing between baskets to increase statistical power. In this work, we provide a systematic comparison of five different Bayesian basket trial designs when sample sizes differ between baskets. We consider the power prior approach with both known and new weighting methods, a design by Fujikawa et al., as well as models based on Bayesian hierarchical modeling and Bayesian model averaging. The results of our simulation study show a high sensitivity to changing sample sizes for Fujikawa's design and the power prior approach. Limiting the amount of shared information was found to be decisive for the robustness to varying basket sizes. In combination with the power prior approach, this resulted in the best performance and the most reliable detection of an effect of the treatment under investigation and its absence.