Interpretable Vision-Language Survival Analysis with Ordinal Inductive Bias for Computational Pathology

TL;DR

This paper introduces a novel vision-language survival analysis framework for computational pathology that leverages foundation models, textual prognostic priors, and ordinal prompts to improve interpretability and data efficiency in prognostic predictions from gigapixel images.

Contribution

It proposes the first vision-language-based survival analysis paradigm that enhances interpretability and data efficiency in computational pathology, overcoming limitations of existing methods.

Findings

Effective prognostic predictions on five datasets

Enhanced interpretability via Shapley values

Improved data efficiency with foundation models

Abstract

Histopathology Whole-Slide Images (WSIs) provide an important tool to assess cancer prognosis in computational pathology (CPATH). While existing survival analysis (SA) approaches have made exciting progress, they are generally limited to adopting highly-expressive network architectures and only coarse-grained patient-level labels to learn visual prognostic representations from gigapixel WSIs. Such learning paradigm suffers from critical performance bottlenecks, when facing present scarce training data and standard multi-instance learning (MIL) framework in CPATH. To overcome it, this paper, for the first time, proposes a new Vision-Language-based SA (VLSA) paradigm. Concretely, (1) VLSA is driven by pathology VL foundation models. It no longer relies on high-capability networks and shows the advantage of data efficiency. (2) In vision-end, VLSA encodes textual prognostic prior and then employs it as auxiliary signals to guide the aggregating of visual prognostic features at instance level, thereby compensating for the weak supervision in MIL. Moreover, given the characteristics of SA, we propose i) ordinal survival prompt learning to transform continuous survival labels into textual prompts; and ii) ordinal incidence function as prediction target to make SA compatible with VL-based prediction. Notably, VLSA's predictions can be interpreted intuitively by our Shapley values-based method. The extensive experiments on five datasets confirm the effectiveness of our scheme. Our VLSA could pave a new way for SA in CPATH by offering weakly-supervised MIL an effective means to learn valuable prognostic clues from gigapixel WSIs. Our source code is available at https://github.com/liupei101/VLSA.