Advances in Nanoparticle-Based Targeted Drug Delivery Systems for Colorectal Cancer Therapy: A Review

TL;DR

This review discusses recent advancements in nanoparticle-based drug delivery systems for colorectal cancer, highlighting their design, benefits, challenges, and future potential to improve targeted therapy and reduce side effects.

Contribution

It provides a comprehensive overview of various nanoparticle types and their mechanisms, emphasizing recent progress and future directions in CRC targeted drug delivery.

Findings

Nanoparticles improve targeting and reduce toxicity in CRC therapy.

Different nanoparticle types offer unique advantages and challenges.

Clinical translation remains a significant hurdle.

Abstract

Colorectal cancer (CRC) continues to be a significant global health burden, prompting the need for more effective and targeted therapeutic strategies. Nanoparticle-based drug delivery systems have emerged as a promising approach to address the limitations of conventional chemotherapy, offering enhanced specificity, reduced systemic toxicity, and improved therapeutic outcomes. This paper provides an in-depth review of the current advancements in the application of nanoparticles as vehicles for targeted drug delivery in CRC therapy. It covers a variety of nanoparticle types, including liposomes, polymeric nanoparticles, dendrimers, and mesoporous silica nanoparticles (MSNs), with a focus on their design, functionalization, and mechanisms of action. This review also examines the challenges associated with the clinical translation of these technologies and explores future directions, emphasizing the potential of nanoparticle-based systems to revolutionize CRC treatment.