Single-distance nano-holotomography with coded apertures

TL;DR

This paper introduces a novel single-distance nano-holotomography method using coded apertures and joint reconstruction, enabling high-resolution 3D imaging without multiple measurements, thus improving temporal resolution and simplifying alignment.

Contribution

The paper presents a new single-distance approach with coded apertures and joint reconstruction, eliminating the need for multiple tomograms and enhancing imaging efficiency.

Findings

Validated through simulations with artifact-free reconstructions

Achieves high-resolution 3D imaging from a single distance

Simplifies experimental setup and improves temporal resolution

Abstract

High-resolution phase-contrast 3D imaging using nano-holotomography typically requires collecting multiple tomograms at varying sample-to-detector distances, usually 3 to 4. This multi-distance approach significantly limits temporal resolution, making it impractical for operando studies. Moreover, shifting the sample complicates reconstruction, requiring precise alignment and interpolation to correct for shift-dependent magnification on the detector. In response, we propose and validate through simulations a novel single-distance approach that leverages coded apertures to structure beam illumination while the sample rotates. This approach is made possible by our proposed joint reconstruction scheme, which integrates coded phase retrieval with 3D tomography. This scheme ensures data consistency and achieves artifact-free reconstructions from a single distance.