Bioimpedance a Diagnostic Tool for Tobacco Induced Oral Lesions: a Mixed Model cross-sectional study

TL;DR

This study evaluates bioimpedance spectroscopy as a diagnostic tool for tobacco-induced oral lesions, demonstrating high sensitivity and specificity, and suggesting its utility in primary healthcare for early detection.

Contribution

It validates bioimpedance as an effective, non-invasive diagnostic method for oral lesions caused by tobacco, with promising accuracy for clinical use.

Findings

Bioimpedance values are significantly lower in OPMD and OSCC compared to controls.

The diagnostic method achieved 95.9% sensitivity and 86.7% specificity.

Bioimpedance can aid in early detection and management of oral lesions.

Abstract

Introduction: Electrical impedance spectroscopy (EIS) has recently developed as a novel diagnostic device for screening and evaluating cervical dysplasia, prostate cancer, breast cancer and basal cell carcinoma. The current study aimed to validate and evaluate bioimpedance as a diagnostic tool for tobacco-induced oral lesions. Methodology: The study comprised 50 OSCC and OPMD tissue specimens for in-vitro study and 320 subjects for in vivo study. Bioimpedance device prepared and calibrated. EIS measurements were done for the habit and control groups and were compared. Results: The impedance value in the control group was significantly higher compared to the OPMD and OSCC groups. Diagnosis based on BIS measurements has a sensitivity of 95.9% and a specificity of 86.7%. Conclusion: Bioimpedance device can help in decision-making for differentiating OPMD and OSCC cases and their management, especially in primary healthcare settings. Keywords: Impedance, Cancer, Diagnosis, Device, Community