Discrete-time treatment number
N.E. Clarke (Acadia Univ.), K.L. Collins (Wesleyan Univ.), M.E. Messinger (Mt. Allison Univ.), A.N. Trenk (Wellesley Coll.), A. Vetta (McGill Univ.)

TL;DR
This paper introduces the discrete-time treatment number for graphs, analyzing how to optimally treat vertices over time with multiple states to minimize treatments, and explores bounds, special cases, and graph modifications affecting this parameter.
Contribution
It defines the discrete-time treatment number, establishes bounds based on pathwidth, and characterizes graphs with minimal treatments, including effects of subdivision and specific graph classes.
Findings
Treatment number bounded by pathwidth-based formula
Exact treatment number for grid graphs is rac{1+n}{2}rac{1+n}{2}
Subdivision of edges can reduce treatment number
Abstract
We introduce the discrete-time treatment number of a graph, in which each vertex is in exactly one of three states at any given time-step: compromised, vulnerable, or treated. Our treatment number is distinct from other graph searching parameters that use only two states, such as the firefighter problem or Bernshteyn and Lee's inspection number. Vertices represent individuals and edges exist between individuals with close connections. Each vertex starts out as compromised; it can become compromised again even after treatment. Our objective is to treat the entire population so that at the last time-step, no members are vulnerable or compromised, while minimizing the maximum number of treatments that occur at each time-step. This minimum is the treatment number, and it depends on the choice of a pre-determined length of time that a vertex can remain in a treated state and length of…
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Taxonomy
TopicsInfluenza Virus Research Studies · vaccines and immunoinformatics approaches · Hepatitis B Virus Studies
