Harmonized connectome resampling for variance in voxel sizes
Elyssa M. McMaster, Nancy R. Newlin, Gaurav Rudravaram, Adam M., Saunders, Aravind R. Krishnan, Lucas W. Remedios, Michael E. Kim, Hanliang, Xu, Derek B. Archer, Kurt G. Schilling, Fran\c{c}ois Rheault, Laurie E., Cutting, and Bennett A. Landman
TL;DR
This paper investigates how voxel resolution affects diffusion MRI connectomes and recommends resampling data to 1 mm isotropic resolution to improve robustness and consistency in tractography results.
Contribution
It provides a comprehensive analysis of voxel size effects on connectome quality and proposes a harmonized resampling approach for better reproducibility.
Findings
Higher resolution improves connectome similarity.
Resampling to 1 mm isotropic resolution enhances robustness.
Down-sampling does not negate the benefits of higher resolution.
Abstract
To date, there has been no comprehensive study characterizing the effect of diffusion-weighted magnetic resonance imaging voxel resolution on the resulting connectome for high resolution subject data. Similarity in results improved with higher resolution, even after initial down-sampling. To ensure robust tractography and connectomes, resample data to 1 mm isotropic resolution.
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