Predicting the Progression of Cancerous Tumors in Mice: A Machine and Deep Learning Intuition

TL;DR

This study uses AI, including machine learning and deep learning, to predict tumor progression in mice under various treatments, demonstrating that neural networks outperform other models and identify the most effective treatment regimen.

Contribution

Introduces a novel AI modeling approach combining machine learning and deep learning to predict cancer treatment outcomes in mice, validated with synthetic data.

Findings

ANN outperforms other models in prediction accuracy

mNP-FDG identified as the most effective treatment

Tumor eradication predicted in approximately 13 days

Abstract

The study explores Artificial Intelligence (AI) powered modeling to predict the evolution of cancer tumor cells in mice under different forms of treatment. The AI models are analyzed against varying ambient and systemic parameters, e.g. drug dosage, volume of the cancer cell mass, and time taken to destroy the cancer cell mass. The data required for the analysis have been synthetically extracted from plots available in both published and unpublished literature (primarily using a Matlab architecture called "Grabit"), that are then statistically standardized around the same baseline for comparison. Three forms of treatment are considered - saline (multiple concentrations used), magnetic nanoparticles (mNPs) and fluorodeoxyglycose iron oxide magnetic nanoparticles (mNP-FDGs) - analyzed using three Machine Learning (ML) algorithms, Decision Tree (DT), Random Forest (RF), Multilinear Regression (MLR), and a Deep Learning (DL) module, the Adaptive Neural Network (ANN). The AI models are trained on 60-80% data, the rest used for validation. Assessed over all three forms of treatment, ANN consistently outperforms other predictive models. Our models predict mNP-FDG as the most potent treatment regime that kills the cancerous tumor completely in ca 13 days from the start of treatment. The models can be generalized to other forms of cancer treatment regimens.