Prediction of the treatment effect of FLASH radiotherapy with Circular Electron-Positron Collider (CEPC) synchrotron radiation

TL;DR

This study evaluates the potential of CEPC synchrotron radiation for FLASH radiotherapy, using simulation and modeling to predict treatment effects and demonstrate its suitability for advanced cancer treatment modalities.

Contribution

It introduces a novel simulation-based approach to predict FLASH radiotherapy effects using CEPC synchrotron radiation, highlighting its advantages for medical applications.

Findings

CEPC synchrotron radiation can produce ultra-high dose rates suitable for FLASH radiotherapy.

Simulation predicts effective treatment effects with CEPC radiation in FLASH modality.

CEPC beam is identified as one of the best options for FLASH radiotherapy.

Abstract

The Circular Electron-Positron Collider (CEPC) can also work as a powerful and excellent synchrotron light source, which can generate high-quality synchrotron radiation. This synchrotron radiation has potential advantages in the medical field, with a broad spectrum, with energies ranging from visible light to x-rays used in conventional radiotherapy, up to several MeV. FLASH radiotherapy is one of the most advanced radiotherapy modalities. It is a radiotherapy method that uses ultra-high dose rate irradiation to achieve the treatment dose in an instant; the ultra-high dose rate used is generally greater than 40 Gy/s, and this type of radiotherapy can protect normal tissues well. In this paper, the treatment effect of CEPC synchrotron radiation for FLASH radiotherapy was evaluated by simulation. First, Geant4 simulation was used to build a synchrotron radiation radiotherapy beamline station, and then the dose rate that CEPC can produce was calculated. Then, a physicochemical model of radiotherapy response kinetics was established, and a large number of radiotherapy experimental data were comprehensively used to fit and determine the functional relationship between the treatment effect, dose rate and dose. Finally, the macroscopic treatment effect of FLASH radiotherapy was predicted using CEPC synchrotron radiation light through the dose rate and the above-mentioned functional relationship. The results show that CEPC synchrotron radiation beam is one of the best beams for FLASH radiotherapy.