Privacy-Preserving and Trustworthy Deep Learning for Medical Imaging

TL;DR

This paper systematically reviews and classifies privacy-enhancing technologies for deep learning in medical imaging, focusing on practical integration, challenges, and future research directions to ensure privacy without compromising efficiency and accuracy.

Contribution

It provides a taxonomy of PETs tailored for Deep Radiomics, practical hybrid constructions, and insights into integration challenges and solutions.

Findings

Classified existing PETs and their suitability for Deep Radiomics

Presented hybrid PET constructions for practical use

Identified challenges and proposed future research directions

Abstract

The shift towards efficient and automated data analysis through Machine Learning (ML) has notably impacted healthcare systems, particularly Radiomics. Radiomics leverages ML to analyze medical images accurately and efficiently for precision medicine. Current methods rely on Deep Learning (DL) to improve performance and accuracy (Deep Radiomics). Given the sensitivity of medical images, ensuring privacy throughout the Deep Radiomics pipeline-from data generation and collection to model training and inference-is essential, especially when outsourced. Thus, Privacy-Enhancing Technologies (PETs) are crucial tools for Deep Radiomics. Previous studies and systematization efforts have either broadly overviewed PETs and their applications or mainly focused on subsets of PETs for ML algorithms. In Deep Radiomics, where efficiency, accuracy, and privacy are crucial, many PETs, while theoretically applicable, may not be practical without specialized optimizations or hybrid designs. Additionally, not all DL models are suitable for Radiomics. Consequently, there is a need for specialized studies that investigate and systematize the effective and practical integration of PETs into the Deep Radiomics pipeline. This work addresses this research gap by (1) classifying existing PETs, presenting practical hybrid PETS constructions, and a taxonomy illustrating their potential integration with the Deep Radiomics pipeline, with comparative analyses detailing assumptions, architectural suitability, and security, (2) Offering technical insights, describing potential challenges and means of combining PETs into the Deep Radiomics pipeline, including integration strategies, subtilities, and potential challenges, (3) Proposing potential research directions, identifying challenges, and suggesting solutions to enhance the PETs in Deep Radiomics.