A Thermal Study of Terahertz Induced Protein Interactions

TL;DR

This study models how Terahertz radiation affects protein heat dissipation, showing potential for controlled intra-body heating to influence thermally-gated ion channels, with numerical and experimental validation.

Contribution

It introduces a mathematical heat diffusion framework for analyzing THz-protein interactions and demonstrates how to control protein temperature changes in biological environments.

Findings

Resonant THz absorption causes measurable temperature increases in proteins.

Controlled heating can modulate ion channel opening probabilities.

Numerical and experimental methods validate the thermal effects of THz radiation.

Abstract

Proteins can be regarded as thermal nanosensors in an intra-body network. Upon being stimulated by Terahertz (THz) frequencies that match their vibrational modes, protein molecules experience resonant absorption and dissipate their energy as heat, undergoing a thermal process. This paper aims to analyze the effect of THz signaling on the protein heat dissipation mechanism. We therefore deploy a mathematical framework based on the heat diffusion model to characterize how proteins absorb THz-electromagnetic (EM) energy from the stimulating EM fields and subsequently release this energy as heat to their immediate surroundings. We also conduct a parametric study to explain the impact of the signal power, pulse duration, and interparticle distance on the protein thermal analysis. In addition, we demonstrate the relationship between the change in temperature and the opening probability of thermally-gated ion channels. Our results indicate that a controlled temperature change can be achieved in an intra-body environment by exciting protein particles at their resonant frequencies. We further verify our results numerically using COMSOL Multiphysics and introduce an experimental framework that assesses the effects of THz radiation on protein particles. We conclude that under controlled heating, protein molecules can serve as hotspots that impact thermally-gated ion channels. Through the presented work, we infer that the heating process can be engineered on different time and length scales by controlling the THz-EM signal input.