An LLM-based Knowledge Synthesis and Scientific Reasoning Framework for Biomedical Discovery

TL;DR

BioLunar is a biomedical discovery platform that uses Large Language Models within a modular, low-code framework to support complex reasoning, evidence integration, and biomarker discovery in cancer research.

Contribution

It introduces BioLunar, a novel LLM-based framework with a low-code interface for scientific reasoning and evidence synthesis in biomedical research.

Findings

Supports complex reasoning over heterogeneous biomedical data

Enables biomarker discovery in oncology

Provides a user-friendly, modular workflow platform

Abstract

We present BioLunar, developed using the Lunar framework, as a tool for supporting biological analyses, with a particular emphasis on molecular-level evidence enrichment for biomarker discovery in oncology. The platform integrates Large Language Models (LLMs) to facilitate complex scientific reasoning across distributed evidence spaces, enhancing the capability for harmonizing and reasoning over heterogeneous data sources. Demonstrating its utility in cancer research, BioLunar leverages modular design, reusable data access and data analysis components, and a low-code user interface, enabling researchers of all programming levels to construct LLM-enabled scientific workflows. By facilitating automatic scientific discovery and inference from heterogeneous evidence, BioLunar exemplifies the potential of the integration between LLMs, specialised databases and biomedical tools to support expert-level knowledge synthesis and discovery.