BayTTA: Uncertainty-aware medical image classification with optimized test-time augmentation using Bayesian model averaging

TL;DR

BayTTA introduces a Bayesian model averaging framework for optimized test-time augmentation, improving accuracy and robustness in medical image classification and other tasks by accounting for model uncertainty.

Contribution

It proposes a novel Bayesian-based TTA method that optimally combines predictions, enhancing performance over traditional averaging approaches.

Findings

BayTTA improves accuracy on medical image datasets.

It enhances robustness of deep learning models.

Effective integration with popular CNN architectures.

Abstract

Test-time augmentation (TTA) is a well-known technique employed during the testing phase of computer vision tasks. It involves aggregating multiple augmented versions of input data. Combining predictions using a simple average formulation is a common and straightforward approach after performing TTA. This paper introduces a novel framework for optimizing TTA, called BayTTA (Bayesian-based TTA), which is based on Bayesian Model Averaging (BMA). First, we generate a prediction list associated with different variations of the input data created through TTA. Then, we use BMA to combine predictions weighted by the respective posterior probabilities. Such an approach allows one to take into account model uncertainty, and thus to enhance the predictive performance of the related machine learning or deep learning model. We evaluate the performance of BayTTA on various public data, including three medical image datasets comprising skin cancer, breast cancer, and chest X-ray images and two well-known gene editing datasets, CRISPOR and GUIDE-seq. Our experimental results indicate that BayTTA can be effectively integrated into state-of-the-art deep learning models used in medical image analysis as well as into some popular pre-trained CNN models such as VGG-16, MobileNetV2, DenseNet201, ResNet152V2, and InceptionRes-NetV2, leading to the enhancement in their accuracy and robustness performance. The source code of the proposed BayTTA method is freely available at: \underline {https://github.com/Z-Sherkat/BayTTA}.