Symmetry engineering in 2D bioelectronics facilitating augmented biosensing interfaces

TL;DR

This paper introduces OXene, a symmetry-engineered 2D bioelectronic material that enhances biosensing interfaces and enables advanced functionalities like high-fidelity signaling and reconfigurable logic, with applications in biomedical recordings.

Contribution

The study presents a novel symmetry-breaking 2D bioelectronic material, OXene, demonstrating its versatile applications in biosensing, signal transmission, and machine learning-enabled physiological analysis.

Findings

OXene improves interfacial impedance and piezoelectric effects.

Demonstrated high-quality physiological recordings in animal models.

Enabled reconfigurable logic gates and wireless signaling.

Abstract

Symmetry lies at the heart of 2D bioelectronics, determining material properties at the fundamental level. Breaking the symmetry allows emergent functionalities and effects. However, symmetry modulation in 2D bioelectronics and the resultant applications have been largely overlooked. Here we devise an oxidized architectural MXene, referred as OXene, that couples orbit symmetric breaking with inverse symmetric breaking to entitle the optimized interfacial impedance and Schottky-induced piezoelectric effects. The resulting OXene validates applications ranging from microelectrode arrays, gait analysis, active transistor matrix, and wireless signaling transmission, which enables highly-fidelity signal transmission and reconfigurable logic gates. Further OXene interfaces are investigated in both rodent and porcine myocardium, featuring high-quality and spatiotemporally resolved physiological recordings, while accurate differentiated predictions, enabled via various machine learning pipelines.