Thermoresponsive PNIPAM/FeRh smart composite activated by magnetic field for doxorubicin release

TL;DR

This study demonstrates a magnetically controlled thermoresponsive PNIPAM/FeRh composite capable of targeted doxorubicin drug release, with confirmed biocompatibility and effective activation by magnetic fields.

Contribution

It introduces a novel magnetocaloric composite that enables controlled drug release through magnetic field activation, combining thermoresponsive polymers with FeRh alloy.

Findings

Magnetic field induces drug release from the composite.

The composite shows high biocompatibility with fibroblast cells.

Drug release can be monitored via spectroscopy techniques.

Abstract

The ability to control by physical properties of the thermoresponsive polymer of PNIPAM by magnetocaloric effect was demonstrated by in-situ experiments on PNIPAM/FeRh smart composite. The concept of drug release loaded in smart composite by applying of 3 T magnetic field was demonstrated using an example of doxorubicin. Released results of the magnetic field applying the drug were detected using IV-VIS and Raman spectroscopy. In vitro, studies have demonstrated a high degree of PNIPAM/FeRh scaffold biocompatibility for primary mouse embryonic fibroblasts (PMEF) cell culture. PMEFs effectively ad-hered to the PNIPAM/FeRh scaffold surface and showed high metabolic and proliferative activity for 72 h after seeding.