Navigating the nexus: a perspective of centrosome -cytoskeleton interactions

TL;DR

This paper reviews the structural and functional relationship between centrosomes and the cytoskeleton, emphasizing their roles in cell polarity, division, and migration, and highlighting the proteins facilitating their interactions.

Contribution

It provides a comprehensive overview of centrosome-cytoskeleton interactions, emphasizing their importance in cellular organization and the regulation of key cellular processes.

Findings

Centrosomes position near the nucleus to establish cell polarity.

Interactions are mediated by crosslinking proteins promoting nucleation.

Coordination between centrosomes and cytoskeleton regulates cell migration and division.

Abstract

A structural relationship between the centrosome and cytoskeleton has been recognized for many years. Centrosomes typically reside near the nucleus, establishing and maintaining the nucleus-centrosome axis. This spatial arrangement is critical for determining cell polarity during interphase and ensuring the proper assembly of the spindle apparatus during mitosis. Centrosomes also engage in physical interactions with various components of the cytoskeleton, balancing internal cellular architecture and polarity in a manner specific to tissue type and developmental stage. Numerous crosslinking proteins facilitate these interactions, promoting both cytoskeletal and centrosomal nucleation. This article provides an overview of how cytoskeletal elements and centrosomes coordinate their actions to regulate complex cellular functions such as cell migration, adhesion, and division. The reciprocal influence between cytoskeletal dynamics and centrosomal positioning underscores their integral roles in cellular organization and function.