Structured Learning of Compositional Sequential Interventions
Jialin Yu, Andreas Koukorinis, Nicol\`o Colombo, Yuchen Zhu, Ricardo, Silva

TL;DR
This paper introduces a structured compositional model for sequential interventions that improves prediction of combined effects in sparse and variable data conditions, advancing causal inference in complex treatment regimes.
Contribution
It proposes an explicit compositional model inspired by causal matrix factorization, clarifying data conditions for identifying combined intervention effects and improving generalization.
Findings
The model's identification properties are established.
Structured models outperform black-box approaches in sparse data scenarios.
Focus on predicting novel intervention combinations rather than matrix completion.
Abstract
We consider sequential treatment regimes where each unit is exposed to combinations of interventions over time. When interventions are described by qualitative labels, such as "close schools for a month due to a pandemic" or "promote this podcast to this user during this week", it is unclear which appropriate structural assumptions allow us to generalize behavioral predictions to previously unseen combinations of interventions. Standard black-box approaches mapping sequences of categorical variables to outputs are applicable, but they rely on poorly understood assumptions on how reliable generalization can be obtained, and may underperform under sparse sequences, temporal variability, and large action spaces. To approach that, we pose an explicit model for composition, that is, how the effect of sequential interventions can be isolated into modules, clarifying which data conditions…
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Taxonomy
TopicsComputational Drug Discovery Methods
MethodsFocus
