Nanoparticle uptake by a semi-permeable, spherical cell from an external planar diffusive field. I. Mathematical model and asymptotic solution

TL;DR

This paper develops a mathematical model and asymptotic solution for nanoparticle diffusion into a semi-permeable spherical cell exposed to an external planar diffusive field, highlighting differences from symmetric conditions.

Contribution

It introduces an effective boundary condition to handle geometry conflict and derives a closed-form asymptotic solution for nanoparticle accumulation inside the cell.

Findings

Closed-form large-time asymptotic concentration inside the cell.

Asymptotic approximation for nanoparticle uptake rate.

Comparison of time dependence with symmetric diffusion scenarios.

Abstract

In this paper we consider the diffusion of nanoparticles taken up by a semi-permeable spherical cell placed in the path of a diffusive particle field generated by an external planar source. The cell interior and exterior are characterized by different diffusive properties, while the cell is able to accommodate a different saturation level of particles at steady state than is present in the external medium. The situation models the practical problem of biological cells exposed from one direction. The conflict of geometries is handled by the introduction of an effective boundary condition at a virtual spherical boundary. A closed-form, large-time asymptotic solution for the local concentration interior to the cell is developed. We consequently derive an asymptotic approximation for the rate of nanoparticle accumulation in the cell. We contrast the resulting time dependence with that of the corresponding quantity found under strictly spherically symmetric conditions.