Learning dynamical models from stochastic trajectories

TL;DR

This paper introduces robust, information-theoretic tools for inferring stochastic dynamical models from noisy biological trajectory data, enabling better understanding of complex biological systems.

Contribution

It develops universal inference methods for stochastic models from experimental trajectories, addressing a key bottleneck in data-driven biophysics.

Findings

Effective inference of Langevin system models

Quantification of entropy production rates

Application to biological trajectory data

Abstract

The dynamics of biological systems, from proteins to cells to organisms, is complex and stochastic. To decipher their physical laws, we need to bridge between experimental observations and theoretical modeling. Thanks to progress in microscopy and tracking, there is today an abundance of experimental trajectories reflecting these dynamical laws. Inferring physical models from noisy and imperfect experimental data, however, is challenging. Because there are no inference methods that are robust and efficient, model reconstruction from experimental trajectories is a bottleneck to data-driven biophysics. In this Thesis, I present a set of tools developed to bridge this gap and permit robust and universal inference of stochastic dynamical models from experimental trajectories. These methods are rooted in an information-theoretical framework that quantifies how much can be inferred from trajectories that are short, partial and noisy. They permit the efficient inference of dynamical models for overdamped and underdamped Langevin systems, as well as the inference of entropy production rates. I finally present early applications of these techniques, as well as future research directions.