QuST: QuPath Extension for Integrative Whole Slide Image and Spatial Transcriptomics Analysis
Chao-Hui Huang, Sara Lichtarge, Diane Fernandez
TL;DR
QuST is a novel tool that integrates whole slide images and spatial transcriptomics data, enabling more comprehensive analysis in digital pathology to advance disease understanding.
Contribution
It introduces QuST, a new software platform that combines WSI and ST data, addressing existing challenges and facilitating integrated analysis in digital pathology.
Findings
Enhanced disease insights through integrated analysis
Bridging WSI and ST data improves diagnostic accuracy
Supports complex spatial transcriptomics and imaging data integration
Abstract
The integration of AI in digital pathology, particularly in whole slide image (WSI) and spatial transcriptomics (ST) analysis, holds immense potential for enhancing our understanding of diseases. Despite challenges such as training pattern preparation and resolution disparities, the convergence of these technologies can unlock new insights. We introduce QuST, a tool that bridges the gap between WSI and ST, underscoring the transformative power of this integrated approach in disease biology.
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Taxonomy
TopicsCell Image Analysis Techniques · Single-cell and spatial transcriptomics