Remote-Controlled Activation of the Release through Drug-Loaded Magnetic Electrospun Fibers

TL;DR

This study introduces a novel magnetic electrospun fiber system for remotely controlled drug release, demonstrating effective, precise, and versatile delivery of hydrophilic and hydrophobic drugs triggered by alternating magnetic fields, with potential biomedical applications.

Contribution

The paper presents a new multifunctional electrospun fiber platform integrating magnetic nanoparticles and mesoporous silica for controlled drug release triggered by magnetic fields, advancing nanomedicine technology.

Findings

Effective magnetic heating up to 8°C in 5 min

Controlled release of ketorolac and curcumin via AMF

Potential applications in transdermal and oncological therapies

Abstract

The integration of magnetic nanoparticles within fibrillar structures represents an interesting avenue for the remotely controlled release of therapeutic agents. This work presents a novel drug release platform based on electrospun magnetic fibers (EMFs) combining drugs, magnetic nanoparticles (MNPs) and mesoporous silica nanoparticles (MSNs) for controlled drug delivery via alternating magnetic fields (AMF). The platform was demonstrated to be versatile and effective for hydrophilic ketorolac (KET) and hydrophobic curcumin (CUR) encapsulation and the major response observed for AMF-triggered release was reached using drug-loaded MSNs within the fibers, providing fine control over drug release patterns. The EMFs exhibited excellent inductive heating capabilities, showing a temperature increase up to 8 {\deg}C within a 5 min AMF pulse. The system is shown to be promising for applications like transdermal pain management, oncological drug delivery, tissue engineering, and wound healing, enabling precise control over drug release in both spatial and temporal dimensions. The findings of this study offer valuable insights into the development of the next generation of smart drug delivery systems, based in multifunctional materials that can be remotely regulated and potentially revolutionize the field of nanomedicine.