DISCRET: Synthesizing Faithful Explanations For Treatment Effect Estimation
Yinjun Wu, Mayank Keoliya, Kan Chen, Neelay Velingker, Ziyang Li,, Emily J Getzen, Qi Long, Mayur Naik, Ravi B Parikh, Eric Wong

TL;DR
DISCRET is a novel self-interpretable framework for individual treatment effect estimation that synthesizes faithful, rule-based explanations, achieving accuracy comparable to black-box models while providing transparent reasoning.
Contribution
It introduces a new RL-based method to generate faithful explanations for ITE models, balancing interpretability and accuracy.
Findings
Outperforms existing self-interpretable models
Achieves accuracy comparable to black-box models
Provides faithful, rule-based explanations
Abstract
Designing faithful yet accurate AI models is challenging, particularly in the field of individual treatment effect estimation (ITE). ITE prediction models deployed in critical settings such as healthcare should ideally be (i) accurate, and (ii) provide faithful explanations. However, current solutions are inadequate: state-of-the-art black-box models do not supply explanations, post-hoc explainers for black-box models lack faithfulness guarantees, and self-interpretable models greatly compromise accuracy. To address these issues, we propose DISCRET, a self-interpretable ITE framework that synthesizes faithful, rule-based explanations for each sample. A key insight behind DISCRET is that explanations can serve dually as database queries to identify similar subgroups of samples. We provide a novel RL algorithm to efficiently synthesize these explanations from a large search space. We…
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Taxonomy
TopicsExplainable Artificial Intelligence (XAI) · Machine Learning in Healthcare · Statistical Methods in Clinical Trials
