Kinematics of Abdominal Aortic Aneurysms
Mostafa Jamshidian, Adam Wittek, Saeideh Sekhavat, Karol Miller

TL;DR
This study introduces a novel, non-invasive, image-based method for analyzing the in vivo kinematics of abdominal aortic aneurysms using 4D-CTA images, providing new insights into wall displacement and strain during the cardiac cycle.
Contribution
The paper presents a patient-specific, non-invasive approach for measuring AAA wall kinematics using deformable image registration and surface fitting, filling a gap in existing biomechanical research.
Findings
AAA wall strains range from 2.62% to 5.54%.
AAA wall strains are significantly lower than healthy aorta.
The method accurately estimates wall displacement and strain.
Abstract
A search in Scopus within "Article title, Abstract, Keywords" unveils 2,444 documents focused on the biomechanics of Abdominal Aortic Aneurysm (AAA), mostly on AAA wall stress. Only 24 documents investigated AAA kinematics, an important topic that could potentially offer significant insights into the biomechanics of AAA. In this paper, we present an image-based approach for patient-specific, in vivo, and non-invasive AAA kinematic analysis using patient's time-resolved 3D computed tomography angiography (4D-CTA) images, with an objective to measure wall displacement and strain during the cardiac cycle. Our approach relies on regularized deformable image registration for estimating wall displacement, estimation of the local wall strain as the ratio of its normal displacement to its local radius of curvature, and local surface fitting with non-deterministic outlier detection for…
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