Unclocklike oscillators with frequency memory for the entrainment of biological clocks

TL;DR

This paper introduces biologically realistic models of oscillators with internal frequency memory that can adapt to external signals, explaining unique entrainment behaviors observed in biological clocks.

Contribution

It proposes new models of frequency-adapting oscillators with memory, capturing unclocklike entrainment phenomena in biological systems.

Findings

Models show broad Arnold tongues and phase plateauing.

Discovery of hysteresis and bistability in entrainment.

Analytical expressions for entrainment phases and cycle shapes.

Abstract

Entrainment experiments on the vertebrate segmentation clock have revealed that embryonic oscillators actively change their internal frequency to adapt to the driving signal. This is neither consistent with a one-dimensional clock model nor with a limit-cycle model, but rather suggests a new "unclocklike" behavior. In this work, we propose simple, biologically realistic descriptions of such internal frequency adaptation, where a phase oscillator activates a memory variable controlling the oscillator's frequency. We study two opposite limits for the control of the memory variable, one with a smooth phase-averaging memory field, and the other with a pulsatile, phase-dependent activation. Both models recapitulate intriguing properties of the entrained segmentation clock, such as very broad Arnold tongues and an entrainment phase plateauing with detuning. We compute analytically multiple properties of such systems, such as entrainment phases and cycle shapes. We further describe new phenomena, including hysteresis in entrainment, bistability in the frequency of the entrained oscillator, and probabilistic entrainment. Our work shows that oscillators with frequency memory can exhibit new classes of unclocklike properties, that can be tested through experimental entrainment.