Precision-based designs for sequential randomized experiments
Mattias Nordin, M{\aa}rten Schultzberg

TL;DR
This paper introduces new sequential experimental designs, FWCID and FPD, that adaptively determine stopping points to ensure desired precision or power, with proven theoretical guarantees and superior performance in simulations.
Contribution
The paper proposes two novel sequential design methods, FWCID and FPD, providing asymptotic guarantees and improved efficiency over existing designs.
Findings
FWCID ensures fixed-width confidence intervals with consistent estimators.
FPD guarantees fixed power without variance knowledge, maintaining coverage.
Simulations show superior performance of proposed designs over standard methods.
Abstract
In this paper, we consider an experimental setting where units enter the experiment sequentially. Our goal is to form stopping rules which lead to estimators of treatment effects with a given precision. We propose a fixed-width confidence interval design (FWCID) where the experiment terminates once a pre-specified confidence interval width is achieved. We show that under this design, the difference-in-means estimator is a consistent estimator of the average treatment effect and standard confidence intervals have asymptotic guarantees of coverage and efficiency for several versions of the design. In addition, we propose a version of the design that we call fixed power design (FPD) where a given power is asymptotically guaranteed for a given treatment effect, without the need to specify the variances of the outcomes under treatment or control. In addition, this design also gives a…
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Taxonomy
TopicsOptimal Experimental Design Methods · Statistical Methods in Clinical Trials · Statistical Methods and Bayesian Inference
