DeepMpMRI: Tensor-decomposition Regularized Learning for Fast and High-Fidelity Multi-Parametric Microstructural MR Imaging

TL;DR

DeepMpMRI is a novel deep learning framework that uses tensor-decomposition regularization to efficiently and accurately estimate multiple microstructural parameters from highly sparse diffusion MRI data, outperforming existing methods.

Contribution

The paper introduces DeepMpMRI, a tensor-decomposition regularized deep learning method for fast, high-fidelity multi-parameter microstructural MRI estimation from sparse data, with adaptive regularization and flexible architecture.

Findings

Outperforms 5 state-of-the-art methods in microstructural parameter estimation.

Achieves 4.5 to 15 times acceleration over dense sampling.

Demonstrates superior results on HCP and Alzheimer's datasets.

Abstract

Deep learning has emerged as a promising approach for learning the nonlinear mapping between diffusion-weighted MR images and tissue parameters, which enables automatic and deep understanding of the brain microstructures. However, the efficiency and accuracy in estimating multiple microstructural parameters derived from multiple diffusion models are still limited since previous studies tend to estimate parameter maps from distinct models with isolated signal modeling and dense sampling. This paper proposes DeepMpMRI, an efficient framework for fast and high-fidelity multiple microstructural parameter estimation from multiple models using highly sparse sampled q-space data. DeepMpMRI is equipped with a newly designed tensor-decomposition-based regularizer to effectively capture fine details by exploiting the high-dimensional correlation across microstructural parameters. In addition, we introduce a Nesterov-based adaptive learning algorithm that optimizes the regularization parameter dynamically to enhance the performance. DeepMpMRI is an extendable framework capable of incorporating flexible network architecture. Experimental results on the HCP dataset and the Alzheimer's disease dataset both demonstrate the superiority of our approach over 5 state-of-the-art methods in simultaneously estimating multi-model microstructural parameter maps for DKI and NODDI model with fine-grained details both quantitatively and qualitatively, achieving 4.5 - 15 $\times$ acceleration compared to the dense sampling of a total of 270 diffusion gradients.