Network Structure Governs Drosophila Brain Functionality

TL;DR

This study demonstrates that the structure of the Drosophila brain network largely determines neural activation patterns, highlighting the importance of topology over neuron complexity in brain function.

Contribution

We developed a computational framework using real connectome data to show network topology's dominant role in neural activation, challenging neuron-centric views.

Findings

Network structure governs activation patterns across models.

Visual and olfactory systems are largely separated at the network level.

Network distance influences activation more than physical distance.

Abstract

How intelligence emerges from living beings has been a fundamental question in neuroscience. However, it remains largely unanswered due to the complex neuronal dynamics and intricate connections between neurons in real neural systems. To address this challenge, we leveraged the largest available adult Drosophila connectome data set, and constructed a comprehensive computational framework based on simplified neuronal activation mechanisms to simulate the observed activation behavior within the connectome. The results revealed that even with rudimentary neuronal activation mechanisms, models grounded in real neural network structures can generate activation patterns strikingly similar to those observed in the actual brain. A significant discovery was the consistency of activation patterns across various neuronal dynamic models. This consistency, achieved with the same network structure, underscores the pivotal role of network topology in neural information processing. These results challenge the prevailing view that solely relies on neuron count or complex individual neuron dynamics. Further analysis demonstrated a near-complete separation of the visual and olfactory systems at the network level. Moreover, we found that the network distance, rather than spatial distance, is the primary determinant of activation patterns. Additionally, our experiments revealed that a reconnect rate of at least 0.1% was sufficient to disrupt the previously observed activation patterns. We also observed synergistic effects between the brain hemispheres: Even with unilateral input stimuli, visual-related neurons in both hemispheres were activated, highlighting the importance of interhemispheric communication. These findings emphasize the crucial role of network structure in neural activation and offer novel insights into the fundamental principles governing brain functionality.