A whole-body mathematical model of cholesterol metabolism and transport

TL;DR

This paper introduces a comprehensive mathematical model of cholesterol metabolism that can simulate drug effects and aid in personalized cardiovascular health interventions.

Contribution

It presents a novel whole-body model based on differential equations, validated with literature data, for simulating cholesterol dynamics and drug impacts.

Findings

Model accurately simulates cholesterol levels

Can predict effects of statins and anti-PCSK9

Supports personalized treatment strategies

Abstract

Cardiovascular diseases are the leading cause of death. Increased levels of plasma cholesterol are consistently associated with an increased risk of cardiovascular disease. As a result, it is imperative that studies are conducted to determine the best course of action to reduce whole-body cholesterol levels. A whole-body mathematical model for cholesterol metabolism and transport is proposed. The model can simulate the effects of lipid-lowering drugs like statins and anti-PCSK9. The model is based on ordinary differential equations and kinetic functions. It has been validated against literature data. It offers a versatile platform for designing personalized interventions for cardiovascular health management.