Functions of Direct and Indirect Pathways for Action Selection Are Quantitatively Analyzed in A Spiking Neural Network of The Basal Ganglia

TL;DR

This paper quantitatively analyzes the roles of direct and indirect pathways in action selection within a spiking neural network model of the basal ganglia, revealing their distinct functions in suppressing or promoting actions.

Contribution

It provides the first quantitative analysis of how the direct pathway and two types of indirect pathways contribute to action selection in the basal ganglia.

Findings

The competition degree determines the selected action.

Intra-channel IP acts as a brake to suppress actions.

Inter-channel IP suppresses competing actions to highlight the desired one.

Abstract

We are concerned about action selection in the basal ganglia (BG). We quantitatively analyze functions of direct pathway (DP) and indirect pathway (IP) for action selection in a spiking neural network with 3 competing channels. For such quantitative analysis, in each channel, we obtain the competition degree ${\cal C}_d$, given by the ratio of strength of DP (${\cal S}_{DP}$) to strength of IP (${\cal S}_{IP}$) (i.e., ${\cal C}_d = {\cal S}_{DP} / {\cal S}_{IP}$). Then, a desired action is selected in the channel with the largest ${\cal C}_d$. Desired action selection is made mainly due to strong focused inhibitory projection to the output nucleus, SNr (substantia nigra pars reticulata) via the DP in the corresponding channel. Unlike the case of DP, there are two types of IPs; intra-channel IP and inter-channel IP, due to widespread diffusive excitation from the STN (subthalamic nucleus). The intra-channel IP serves a function of brake to suppress the desired action selection. In contrast, the inter-channel IP to the SNr in the neighboring channels suppresses competing actions, leading to highlight the desired action selection. In this way, function of the inter-channel IP is opposite to that of the intra-channel IP. However, to the best of our knowledge, no quantitative analysis for such functions of the DP and the two IPs was made. Here, through direct calculations of the DP and the intra- and the inter-channel IP presynaptic currents into the SNr in each channel, we obtain the competition degree of each channel to determine a desired action, and then functions of the DP and the intra- and inter-channel IPs are quantitatively made clear.