System Characterization of a Human-Sized 3D Real-Time Magnetic Particle Imaging Scanner for Cerebral Applications

TL;DR

This paper presents a thoroughly characterized, head-sized 3D magnetic particle imaging scanner designed for human brain applications, demonstrating high-resolution, real-time imaging capabilities suitable for clinical and monitoring purposes.

Contribution

The work introduces an improved, open-source, human-safe MPI scanner with full 3D imaging at 4 Hz, optimized for brain perfusion imaging and potential clinical diagnostics.

Findings

Achieved 3D single- and multi-contrast imaging at 4 Hz

Demonstrated sensitivity and resolution suitable for brain applications

Validated imaging with clinically approved tracer and safety thresholds

Abstract

Since the initial patent in 2001, the Magnetic Particle Imaging (MPI) community has been striving to develop an MPI scanner suitable for human applications. Numerous contributions from different research fields, regarding tracer development, reconstruction methods, hardware engineering, and sequence design have been employed in pursuit of this objective. In this work, we introduce and thoroughly characterize an improved head-sized MPI scanner with an emphasis on human safety. The scanner is operated by open-source software that enables scanning, monitoring, analysis, and reconstruction, designed to be handled by end users. Our primary focus is to present all technical components of the scanner, with the ultimate objective to investigate brain perfusion imaging in phantom experiments. We have successfully achieved full 3D single- and multi-contrast imaging capabilities at a frame rate of 4 Hz with sufficient sensitivity and resolution for brain applications. To assess system characterization, we devised sensitivity, resolution, perfusion, and multi-contrast experiments, as well as field measurements and sequence analysis. The acquired images were captured using a clinically approved tracer and suitable magnetic field strengths, while adhering to the established human peripheral nerve stimulation thresholds. This advanced scanner holds potential as a tomographic imager for diagnosing conditions such as ischemic stroke or intracranial hemorrhage in environments lacking electromagnetic shielding. Furthermore, due to its low power consumption it may have the potential to facilitate long-term monitoring within intensive care units for various applications.