Multistationarity questions in reduced vs extended biochemical networks

TL;DR

This paper investigates how the property of multistationarity in biochemical networks is affected by network modifications, providing new theoretical insights and computational tools for analyzing complex biological systems.

Contribution

It introduces general results on MESSI systems and computes circuits of multistationarity, advancing understanding of network behavior under structural changes.

Findings

Established new results on multistationarity in MESSI systems

Computed circuits of multistationarity for key biochemical networks

Extended previous literature on network modifications and multistationarity

Abstract

We address several questions in reduced versus extended networks via the elimination or addition of intermediate complexes in the framework of chemical reaction networks with mass-action kinetics. We clarify and extend advances in the literature concerning multistationarity in this context. We establish general results about MESSI systems, which we use to compute the circuits of multistationarity for significant biochemical networks.