Light confinement in stratum corneum

TL;DR

This study models how the low water content and resulting refractive index gradient in the stratum corneum influence light confinement, showing increased light intensity in this skin layer, especially in thickened regions like palms and soles.

Contribution

It provides analytical models demonstrating the impact of water content and refractive index gradients on light confinement in the skin's outer layer, highlighting conditions for maximal effect.

Findings

Light intensity in stratum corneum is 11-17% higher than underlying tissue.

Light confinement is most prominent in thickened skin regions.

Effect is significant when stratum corneum exceeds the reduced scattering length.

Abstract

The epidermis is the outermost layer of the skin, and it plays a crucial role in protecting the body from external insults such as UV radiation and physical trauma. The stratum corneum is the topmost layer of the epidermis, composed of dead skin cells and characterized by low water content. This low water content creates a gradient in the refractive index. The current work aims to elucidate the impact of a significant gradient of water content and, consequently, the variations of the refractive index of the skin on light propagation in tissues. Using analytical models of light propagation in single-layer and two-layer tissues, we predict light confinement in the stratum corneum layer. For example, the light intensity in the stratum corneum layer is noticeably (11-17%) higher than in the underlying tissue layer. This effect can be attributed to the high refractive index of the stratum corneum caused by low water content, compared with underlying tissues, and scattering in the stratum corneum layer. The effect is the most prominent for smaller diffuse reflectance of the underlying tissue. Furthermore, the effect is expected to be maximal if the thickness of the stratum corneum layer is more than the reduced scattering length. Therefore, in the visible range of the spectrum, the light confinement phenomena should be more noticable in stratum corneum layers with a thickness of at least 150um, which can be found in the glabrous skin of palms and soles and thickened epidermis-like calluses and corns