Rapid Changes in Synchronizability in Conductance-based Neuronal Networks with Conductance-based Coupling

TL;DR

This study extends the Master Stability Function approach to conductance-based neuronal networks, revealing how synaptic reversal potential and coupling strength influence synchronizability, with implications for understanding neural connectivity dynamics.

Contribution

It introduces an extension of the MSF method to conductance-based synapses in neuronal networks, analyzing stability conditions for synchrony based on network parameters.

Findings

Reversal potential is the key parameter for synchronizability.

Rapid transition between excitatory and inhibitory stability with small voltage changes.

Inhibitory connectivity can form islands of synchronizability at certain coupling strengths.

Abstract

Real neurons connect to each other non-randomly. How the connectivity of networks of conductance-based neuron models like the classical Hodgkin-Huxley model, or the Morris-Lecar model, impacts synchronizability remains unknown. One powerful tool to resolve the synchronizability of these networks is the Master Stability Function (MSF). Here, we apply and extend the MSF approach to networks of Morris-Lecar neurons with conductance-based coupling to determine under which parameters and graphs synchronous solutions are stable. We consider connectivity graphs with a constant row-sum, where the MSF approach can be readily extended to conductance-based synapses rather than the more well-studied diffusive connectivity case, which primarily applies to gap junction connectivity. In this formulation, the synchronous solution is a single, self-coupled or 'autaptic' neuron. We find that the primary determining parameter for the stability of the synchronous solution is, unsurprisingly, the reversal potential, as it largely dictates the excitatory/inhibitory potential of a synaptic connection. However, the change between "excitatory" and "inhibitory'' synapses is rapid, with only a few millivolts separating stability and instability of the synchronous state for most graphs. We also find that for specific coupling strengths (as measured by the global synaptic conductance), islands of synchronizability in the MSF can emerge for inhibitory connectivity. We verified the stability of these islands by direct simulation of pairs of neurons coupled with eigenvalues in the matching spectrum. These results were robust for different transitions to spiking (Hodgkin Class I vs Class II), which displayed very similar synchronizability characteristics.