Laser-driven electron source suitable for single-shot Gy-scale irradiation of biological cells at dose-rates exceeding $10^{10}$ Gy/s
C.A. McAnespie, P. Chaudhary, L. Calvin, M.J.V. Streeter, G., Nersysian, S. J. McMahon, K. M. Prise, and G. Sarri

TL;DR
This paper presents a tunable laser-driven electron source capable of delivering ultra-high dose rates exceeding 10^{10} Gy/s in single shots, enabling new research in biological cell response to intense, rapid radiation exposure.
Contribution
It introduces a novel, tunable laser-driven electron source capable of delivering Gy-scale doses at unprecedented ultra-high dose rates in single shots.
Findings
Single-shot delivery of multi-Gy doses over cm-scale areas
Dose rates in the range of 10^{10} - 10^{12} Gy/s achieved
High spatial uniformity confirmed by Monte-Carlo simulations
Abstract
We report on the first systematic characterisation of a tuneable laser-driven electron source capable of delivering Gy-scale doses in a duration of 10 - 20 ps, thus reaching unprecedented dose rates in the range of Gy/s. Detailed characterisation of the source indicates, in agreement with Monte-Carlo simulations, single-shot delivery of multi-Gy doses per pulse over cm-scale areas, with a high degree of spatial uniformity. The results reported here confirm that a laser-driven source of this kind can be used for systematic studies of the response of biological cells to picosecond-scale radiation at ultra-high dose rates.
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Taxonomy
TopicsRadiation Therapy and Dosimetry · Photoreceptor and optogenetics research · Advanced Fluorescence Microscopy Techniques
