Unveiling the Complexity of Neural Populations: Evaluating the Validity and Limitations of the Wilson-Cowan Model

TL;DR

This paper critically evaluates the Wilson-Cowan neural population model by comparing it with detailed Hodgkin-Huxley network simulations, revealing its limitations and conditions under which it accurately captures complex neural dynamics.

Contribution

It introduces a mean field-based derivation of population dynamics from Hodgkin-Huxley networks and assesses the Wilson-Cowan model's validity across diverse neural behaviors.

Findings

Wilson-Cowan model accurately predicts simple periodic regimes.

Model's accuracy diminishes in complex, aperiodic, or bifurcation regimes.

Neural complexity can be induced by heterogeneity in connectivity and external drive.

Abstract

The population model of Wilson-Cowan is perhaps the most popular in the history of computational neuroscience. It embraces the nonlinear mean field dynamics of excitatory and inhibitory neuronal populations provided via a temporal coarse-graining technique. The traditional Wilson-Cowan equations exhibit either steady-state regimes or else limit cycle competitions for an appropriate range of parameters. As these equations lower the resolution of the neural system and obscure vital information, we assess the validity of mass-type model approximations for complex neural behaviors. Using a large-scale network of Hodgkin-Huxley style neurons, we derive implicit average population dynamics based on mean field assumptions. Our comparison of the microscopic neural activity with the macroscopic temporal profiles reveals dependency on the binary state of interacting subpopulations and the random property of the structural network at the Hopf bifurcation points when different synaptic weights are considered. For substantial configurations of stimulus intensity, our model provides further estimates of the neural population's dynamics official, ranging from simple periodic to quasi-periodic and aperiodic patterns, as well as phase transition regimes. While this shows its great potential for studying the collective behavior of individual neurons particularly concentrating on the occurrence of bifurcation phenomena, we must accept a quite limited accuracy of the Wilson-Cowan approximations-at least in some parameter regimes. Additionally, we report that the complexity and temporal diversity of neural dynamics, especially in terms of limit cycle trajectory, and synchronization can be induced by either small heterogeneity in the degree of various types of local excitatory connectivity or considerable diversity in the external drive to the excitatory pool.