Tumoral Angiogenic Optimizer: A new bio-inspired based metaheuristic
Hern\'andez Rodr\'iguez, Mat\'ias Ezequiel

TL;DR
This paper introduces a novel bio-inspired metaheuristic based on tumor angiogenesis, demonstrating its effectiveness on benchmark and real-world constrained optimization problems with competitive results.
Contribution
A new metaheuristic algorithm inspired by tumor angiogenesis, with parameters set by biological modeling, avoiding arbitrary initialization.
Findings
Achieved competitive results on benchmark functions.
Successfully applied to real-world constrained optimization problems.
Outperformed several known algorithms in tests.
Abstract
In this article, we propose a new metaheuristic inspired by the morphogenetic cellular movements of endothelial cells (ECs) that occur during the tumor angiogenesis process. This algorithm starts with a random initial population. In each iteration, the best candidate selected as the tumor, while the other individuals in the population are treated as ECs migrating toward the tumor's direction following a coordinated dynamics through a spatial relationship between tip and follower ECs. This algorithm has an advantage compared to other similar optimization metaheuristics: the model parameters are already configured according to the tumor angiogenesis phenomenon modeling, preventing researchers from initializing them with arbitrary values. Subsequently, the algorithm is compared against well-known benchmark functions, and the results are validated through a comparative study with Particle…
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Taxonomy
TopicsAngiogenesis and VEGF in Cancer · Hippo pathway signaling and YAP/TAZ · Advanced Numerical Analysis Techniques
