An optimal control approach for the treatment of hepatitis C patients

TL;DR

This paper explores the use of optimal control theory to develop personalized treatment strategies for hepatitis C by modeling disease progression and designing control-based interventions.

Contribution

It introduces a mathematical model of HCV progression and applies optimal control methods to synthesize treatment regimens.

Findings

Feasibility demonstrated for control-based HCV treatment

Mathematical model includes healthy and infected cells, virions

Open-loop control strategies designed for personalized therapy

Abstract

In this article, the feasibility of using optimal control theory will be studied to develop control theoretic methods for personalized treatment of HCV patients. The mathematical model for HCV progression includes compartments for healthy hepatocytes, infected hepatocytes, infectious virions and noninfectious virions. Methodologies have been used from optimal control theory to design and synthesize an open-loop control based treatment regimen for HCV dynamics.