The role of PHF5A in cancer: A review and update

TL;DR

This review summarizes the role of PHF5A, a zinc-finger protein, in cancer development, highlighting its potential as a prognostic marker and therapeutic target due to its involvement in tumor cell proliferation, invasion, and metastasis.

Contribution

It provides an updated synthesis of experimental, animal, and clinical studies on PHF5A's oncogenic functions across various cancers.

Findings

PHF5A is frequently overexpressed in tumor cells.

Knockdown of PHF5A inhibits tumor invasion and metastasis.

Potential for PHF5A-targeted therapies in cancer treatment.

Abstract

PHF5A is a member of the zinc-finger proteins. To advance knowledge on their role in carcinogenesis, data from experimental studies, animal models and clinical studies in different tumorigenesis have been reviewed. Furthermore, PHF5A as an oncogenic function, is frequently expressed in tumor cells and a potential prognostic marker for different cancers. PHF5A is implicated in the regulation of cancer cell proliferation, invasion, migration and metastasis. Knockdown of PHF5A prevented the invasion and metastasis of tumor cells. Here, the role of PHF5A in different cancers and their possible mechanism in relation to recent literature is reviewed and discussed. However, there is an open promising perspective to their therapeutic management for different cancer types.