CRC-ICM: Colorectal Cancer Immune Cell Markers Pattern Dataset

TL;DR

This paper introduces CRC-ICM, a dataset of colon tissue images stained for immune markers, to facilitate research on immune landscapes in colorectal cancer based on tumor location.

Contribution

It provides a new, publicly available image dataset focusing on immune cell markers in CRC tissues, highlighting differences related to tumor location.

Findings

Dataset contains 1756 images from 136 patients.

Images stained for key immune checkpoints like PD-1, LAG3, Tim3.

Accessible via Mendeley dataset portal.

Abstract

Colorectal Cancer (CRC) is the second most common cause of cancer death in the world, ad can be identified by the location of the primary tumor in the large intestine: right and left colon, and rectum. Based on the location, CRC shows differences in chromosomal and molecular characteristics, microbiomes incidence, pathogenesis, and outcome. It has been shown that tumors on left and right sides also have different immune landscape, so the prognosis may be different based on the primary tumor locations. It is widely accepted that immune components of the tumor microenvironment (TME) plays a critical role in tumor development. One of the critical regulatory molecules in the TME is immune checkpoints that as the gatekeepers of immune responses regulate the infiltrated immune cell functions. Inhibitory immune checkpoints such as PD-1, Tim3, and LAG3, as the main mechanism of immune suppression in TME overexpressed and result in further development of the tumor. The images of this dataset have been taken from colon tissues of patients with CRC, stained with specific antibodies for CD3, CD8, CD45RO, PD-1, LAG3 and Tim3. The name of this dataset is CRC-ICM and contains 1756 images related to 136 patients. The initial version of CRC-ICM is published on Elsevier Mendeley dataset portal, and the latest version is accessible via: https://databiox.com