Deep Learning Framework for Spleen Volume Estimation from 2D Cross-sectional Views

TL;DR

This paper introduces a novel deep learning framework that accurately estimates spleen volume from 2D ultrasound segmentations, potentially improving clinical assessment of splenomegaly especially in resource-limited settings.

Contribution

It presents the first direct 3D spleen volume estimation method from 2D segmentations using a variational autoencoder-based approach, outperforming existing techniques.

Findings

Achieved 86.62% and 92.58% accuracy with single- and dual-view inputs.

Produced clinically useful 95% confidence intervals for volume estimates.

Surpassed traditional linear regression and 2D-3D reconstruction methods.

Abstract

Abnormal spleen enlargement (splenomegaly) is regarded as a clinical indicator for a range of conditions, including liver disease, cancer and blood diseases. While spleen length measured from ultrasound images is a commonly used surrogate for spleen size, spleen volume remains the gold standard metric for assessing splenomegaly and the severity of related clinical conditions. Computed tomography is the main imaging modality for measuring spleen volume, but it is less accessible in areas where there is a high prevalence of splenomegaly (e.g., the Global South). Our objective was to enable automated spleen volume measurement from 2D cross-sectional segmentations, which can be obtained from ultrasound imaging. In this study, we describe a variational autoencoder-based framework to measure spleen volume from single- or dual-view 2D spleen segmentations. We propose and evaluate three volume estimation methods within this framework. We also demonstrate how 95% confidence intervals of volume estimates can be produced to make our method more clinically useful. Our best model achieved mean relative volume accuracies of 86.62% and 92.58% for single- and dual-view segmentations, respectively, surpassing the performance of the clinical standard approach of linear regression using manual measurements and a comparative deep learning-based 2D-3D reconstruction-based approach. The proposed spleen volume estimation framework can be integrated into standard clinical workflows which currently use 2D ultrasound images to measure spleen length. To the best of our knowledge, this is the first work to achieve direct 3D spleen volume estimation from 2D spleen segmentations.